Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening

Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening.

Mitochondrial membrane permeability transition (MPT) plays a crucial role in apoptotic tail shortening during anuran metamorphosis. L-carnitine is known to shuttle free fatty acids (FFAs) from the cytosol into mitochondria matrix for β-oxidation and energy production, and in a previous study we found that treatment with L-carnitine suppresses 3, 3', 5-triiodothyronine (T3 ) and FFA-induced MPT ...

Thyroid hormone-induced regulation of polyribosomal translational efficiency in tadpole tail muscle.

A variety of mechanisms have been proposed to explain the thyroid hormone-induced involution of the anuran tadpole tail, but supportive evidence for any of these proposals is inconclusive. Our in uiuo findings support and extend the hypothesis that a decrease in the rate of protein synthesis in tadpole tail tissue is an early and progressively sustained effect induced by in uiuo administration ...

Acetyl-L-Carnitine Monograph

Introduction Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, simila...

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy